Humoral immune responses to periodontal pathogens in the elderly
Uttom Shet, 오희균, 정현주, 김영준, 김옥수, 임회정, 신민호, 이석우,
소속 상세정보
( Uttom Shet ) - Chonnam National University School of Dentistry Department of Oral & Maxillofacial Surgery
오희균 ( Oh Hee-Kyun ) - Chonnam National University School of Dentistry Department of Oral and Maxillofacial Surgery
정현주 ( Chung Hyun-Ju ) - Chonnam National University School of Dentistry Department of Periodontology
김영준 ( Kim Young-Joon ) - Chonnam National University School of Dentistry Department of Periodontology
김옥수 ( Kim Ok-Su ) - Chonnam National University School of Dentistry Department of Periodontology
임회정 ( Lim Hoi-Jeong ) - Chonnam National University School of Dentistry Department of Orthodontics
신민호 ( Shin Min-Ho ) - Chonnam National University Medical School Department of Preventive Medicine
이석우 ( Lee Seok-Woo ) - Chonnam National University School of Dentistry Department of Dental Education
KMID : 0363020150450050178
Abstract
Purpose: Elderly people are thought to be more susceptible to periodontal disease due to reduced immune function associated with aging. However, little information is available on the nature of immune responses against putative periodontal pathogens in geriatric patients. The purpose of this study was to evaluate the serum IgG antibody responses to six periodontal pathogens in geriatric subjects.
Methods: The study population consisted of 85 geriatric patients and was divided into three groups: 29 mild (MCP), 27 moderate (MoCP) and 29 severe (SCP) chronic periodontitis patients. Serum levels of IgG antibody to Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Prevotella intermedia were measured by enzyme-linked immunosorbent assay (ELISA) and compared among the groups.
Results: All three groups showed levels of serum IgG in response to P. gingivalis, A. actinomycetemcomitans, and P. intermedia that were three to four times higher than levels of IgG to T. forsythia, T. denticola, and F. nucleatum. There were no significant differences among all three groups in IgG response to P. gingivalis (P=0.065), T. forsythia (P=0.057), T. denticola (P=0.1), and P. intermedia (P=0.167), although the IgG levels tended to be higher in patients with SCP than in those with MCP or MoCP (with the exception of those for P. intermedia). In contrast, there were significant differences among the groups in IgG levels in response to F. nucleatum (P=0.001) and A. actinomycetemcomitans (P=0.003). IgG levels to A. actinomycetemcomitans were higher in patients with MCP than in those with MoCP or SCP.
Conclusions: When IgG levels were compared among three periodontal disease groups, only IgG levels to F. nucleatum significantly increased with the severity of disease. On the contrary, IgG levels to A. actinomycetemcomitans decreased significantly in patients with SCP compared to those with MCP. There were no significant differences in the IgG levels for P. gingivalis, T. forsythia, T. denticola, and P. intermedia among geriatric patients with chronic periodontitis.
키워드
Chronic periodontitis; Disease progression; Enzyme-Linked Immunosorbent Assay; Geriatrics; Immunoglobulin G
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